Small molecules & peptides

(R)-SDM-8 standard

Reference standard for [¹⁸F]SDM-8

(R)-4-(3,5-difluorophenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one; 2-​Pyrrolidinone, 4-​(3,​5-​difluorophenyl)​-​1-​[(3-​methyl-​4-​pyridinyl)​methyl]​-​, (4R)​-; (R)-SDM-8 standard; (R)-SynVesT-1 standard; (R)-MNI-1126 standard

(R)-4-(3-Fluoro-5-(fluoro)phenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one

Quality

Research Chemical

Characteristics

Molar mass 302.32

CAS RN [2242777-37-1]

Purity ≥ 95 %

  • Colorless to off-white solid
  • soluble in dimethyl sulfoxide, dichloromethane, methanol, ethyl acetate

Certificates

CoA: appearance, ¹H and ¹⁹F NMR spectra (identity), HPLC (purity), chiral HPLC (enantiomeric purity)

Literature

Li S. et al. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem. Neurosci.2019, 10, 1544–1554.

Li S. et al. ¹⁸F-SDM-8: A novel radiotracer for PET imaging of synaptic density. J. Nucl. Med.2018, 59, supplement 1, 68.

Li S. et al. First-in-human Evaluation of ¹⁸F-SDM-8, A Novel Radiotracer for PET Imaging of Synaptic Vesicle Glycoprotein 2A. J. Nucl. Med.2019, 60, supplement 1, 49.

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Product No.: 3427

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