Small molecules & peptides

SDM-8 tin precursor

Precursor for [¹⁸F]SDM-8

[¹⁸F]SDM-8 tin precursor; 2-​Pyrrolidinone, 4-​[3-​fluoro-​5-​(trimethylstannyl)​phenyl]​-​1-​[(3-​methyl-​4-​pyridinyl)​methyl]​-​, (4R)​-; SynVesT1 precursor



Research Chemical


Molar mass 447.13

CAS RN [2289636-79-7]

Purity ≥ 95 %

  • Colorless to yellowish oil or colorless to off-white solid
  • soluble in dimethyl sulfoxide, dichloromethane, chloroform, ethyl acetate


CoA: appearance, ¹H and ¹⁹F NMR spectra (identity), HPLC (purity)


Li S. et al. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem. Neurosci. 2019, 10, 1544–1554.

Li S. et al. ¹⁸F-SDM-8: A novel radiotracer for PET imaging of synaptic density. J. Nucl. Med. 2018, 59, supplement 1, 68.

Li S. et al. First-in-human Evaluation of ¹⁸F-SDM-8, A Novel Radiotracer for PET Imaging of Synaptic Vesicle Glycoprotein 2A. J. Nucl. Med. 2019, 60, supplement 1, 49.

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