Small molecules & peptides

UCB-J precursor (GMP)

Precursor for [¹¹C]UCB-J

[¹¹C]UCB-J precursor

(R)-3-(Difluoroboranyl)-4-((2-oxo-4-(3,4,5-trifluorophenyl)pyrrolidin-1-l)methyl)-pyridin-1-ium fluoride


GMP Product


Molar mass 374.09

CAS RN [not yet assigned]

Purity ≥ 97 %

  • colorless to off-white solid
  • Tested for bioburden and bacterial endotoxins.


CoA: appearance, ¹H and ¹⁹F NMR spectra, HPLC, chiral HPLC


Nabulsi N. et al. Synthesis and Preclinical Evaluation of ¹¹C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J. Nucl. Med. 2016, 57, 777–784.

Mercier J. et al. Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands. Chem. Med. Chem. 2014, 9, 693–698.

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