Small molecules & peptides

UCB-J bromo precursor

Precursor for [¹¹C]UCB-J

(4R)-1-(3-Bromo-pyridin-4-ylmethyl)-4-(3,4,5-trifluoro-phenyl)-pyrrolidin-2-one; 2-Pyrrolidinone, 1-[(3-bromo-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)-



Research Chemical


Molar mass 385.18

CAS RN [2098041-10-0]

Purity ≥ 95 %

  • white to off-white solid
  • soluble in ethyl acetate, dichloromethane, dimethyl sulfoxide


CoA: appearance, ¹H and ¹⁹F NMR spectra (identity, purity), chiral HPLC (enantiomeric purity)


Nabulsi N. et al. Synthesis and Preclinical Evaluation of ¹¹C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J. Nucl. Med. 2016, 57, 777–784.

Mercier J. et al. Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands. Chem. Med. Chem. 2014, 9, 693–698.

WO2017090354, Aromatic Compound [¹¹C]-Methylation Method

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