Small molecules & peptides
UCB-J bromo precursor
Precursor for [¹¹C]UCB-J
(4R)-1-(3-Bromo-pyridin-4-ylmethyl)-4-(3,4,5-trifluoro-phenyl)-pyrrolidin-2-one; 2-Pyrrolidinone, 1-[(3-bromo-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)-, (4R)-
(4R)-1-[(3-bromo-4-pyridyl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
Quality
Research Chemical
Characteristics
Molar mass 385.18
CAS RN [2098041-10-0]
Purity ≥ 95 %
- white to off-white solid
- soluble in ethyl acetate, dichloromethane, dimethyl sulfoxide
Certificates
CoA: appearance, ¹H and ¹⁹F NMR spectra (identity, purity), chiral HPLC (enantiomeric purity)
Literature
Nabulsi N. et al. Synthesis and Preclinical Evaluation of ¹¹C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J. Nucl. Med. 2016, 57, 777–784.
Mercier J. et al. Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands. Chem. Med. Chem. 2014, 9, 693–698.
WO2017090354, Aromatic Compound [¹¹C]-Methylation Method
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| Product | Product No. | Filling amount | Quantity | ||
|---|---|---|---|---|---|
| /products/small-molecules-and-peptides/chemical/a05d2d15-449f-423c-85e3-9c174bca7605 | Precursor | Product No.: 3423 |
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