Small molecules & peptides
TE-TDDPN
Precursor for [¹⁸F]FE-DPN by nucleophilic radiosynthesis
6-O-(2-tosyloxyethyl)-6-O-desmethyl-3-O-trityl-diprenorphine
(5R,6R,7R,9R,13S,14S)-17-cyclopropylmethyl-4,5-epoxy-18,19-dihydro-6-(2-(4-toluene-sulfonyloxy)ethoxy)-3-triphenylmethoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Quality
Research Chemical
Characteristics
Molar mass 852.09
CAS RN [2781112-55-6]
Purity ≥ 94 %
- Yellowish to off-white solid
- soluble in chloroform, dichloromethane, dimethyl sulfoxide, methanol, ethanol, acetone
Certificates
CoA: off-white to yellowish solid, ¹H NMR spectrum (identity), HRMS (identity), HPLC (purity)
Literature
Marton, J. et al. A New Precursor for the Radiosynthesis of 6-O-(2[¹⁸F]Fluoroethyl)-6-O-Desmethyl-Diprenorphine ([¹⁸F]FE-DPN) by Nucleophilic Radiofluorination. Lett. Org. Chem. 2021, 18, 344–352.
Levinstein, M. R. et al. 6-O-(2-[18F]Fluoroethyl)-6-O-Desmethyl-Diprenorphine ([18F] FE-DPN) Preferentially Binds to Mu Opioid Receptors In Vivo. Mol. Imaging Biol. 2023, 25, 384–390.
Németh, E. et al. Optimization of a Nucleophilic Two-Step Radiosynthesis of 6-O-(2-[18F]fluoroethyl)-6-O-Desmethyl-Diprenorphine ([18F]FE-DPN) for PET Imaging of Brain Opioid Receptors. Int. J. Mol. Sci. 2023, 24, 13152.
Bettcher, B. et al. [18F]FE-DPN 6-O-(2-[18F]fluoroethyl)-6-O-desmethyl-diprenorphine with Dynamic PET Imaging for Brain mu-Opioid Receptors in Nonhuman Primate Models; XIV International Symposium on Functional NeuroReceptor Mapping of the Living Brain 2024, Montreal, Canada, 18-21th May
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| Product | Product No. | Filling amount | Quantity | ||
|---|---|---|---|---|---|
| /products/small-molecules-and-peptides/chemical/411f4e47-9263-493a-9dba-3ca42e66396d | Precursor | Product No.: 2042 |
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