Small molecules & peptides


Precursor for [¹⁸F]FE-DPN by nucleophilic radiosynthesis




Research Chemical


Molar mass 852.09

CAS RN [2781112-55-6]

Purity ≥ 94 %

  • Yellowish to off-white solid
  • soluble in chloroform, dichloromethane, dimethyl sulfoxide, methanol, ethanol, acetone


CoA: off-white to yellowish solid, ¹H NMR spectrum (identity), HRMS (identity), HPLC (purity)


Marton, J. et al. A New Precursor for the Radiosynthesis of 6-O-(2[¹⁸F]Fluoroethyl)-6-O-Desmethyl-Diprenorphine ([¹⁸F]FE-DPN) by Nucleophilic Radiofluorination. Lett. Org. Chem. 2021, 18, 344–352.

Levinstein, M. R. et al. 6-O-(2-[18F]Fluoroethyl)-6-O-Desmethyl-Diprenorphine ([18F] FE-DPN) Preferentially Binds to Mu Opioid Receptors In Vivo. Mol. Imaging Biol. 2023, 25, 384–390.

Németh, E. et al. Optimization of a Nucleophilic Two-Step Radiosynthesis of 6-O-(2-[18F]fluoroethyl)-6-O-Desmethyl-Diprenorphine ([18F]FE-DPN) for PET Imaging of Brain Opioid Receptors. Int. J. Mol. Sci. 2023, 24, 13152.

Bettcher, B. et al. [18F]FE-DPN 6-O-(2-[18F]fluoroethyl)-6-O-desmethyl-diprenorphine with Dynamic PET Imaging for Brain mu-Opioid Receptors in Nonhuman Primate Models; XIV International Symposium on Functional NeuroReceptor Mapping of the Living Brain 2024, Montreal, Canada, 18-21th May

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