Small molecules & peptides


Precursor for [¹¹C]Flumazenil and precursor for 5-(2'-[¹⁸F]fluoroethyl)Flumazenil ([¹⁸F]FEF)

8-Fluoro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester; Desmethyl-FMZ; Ro 15-5528

CA index name: 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-6-oxo-, ethyl ester


Research Chemical


Molar mass 289.26

CAS RN [79089-72-8]

Purity ≥ 95 %

  • Colorless crystals


CoA: appearance, ¹H and ¹⁹F NMR spectra


Nagren K. et al. Methylation of amide and thiol functions with [¹¹C]methyl triflate, as exemplified by [¹¹C]NMSP, [¹¹C]flumazenil and [¹¹C]methionine. J. Labelled Compd. Radiopharm. 1998, 41, 831–841.

Maziere M. et al. Synthesis of Ethyl 8-Fluoro-5,6-dihydro-5-[¹¹C]methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (RO 15.1788–11C): A Specific Radioligand for the In Vivo Study of Central Benzodiazepine Receptors by Positron Emmission Tomography. Int. J. Appl. Radiat. Isot. 1984, 35, 973–976.

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