Small molecules & peptides


Reference standard for [¹¹C]Flumazenil and reference standard for [¹⁸F]Flumazenil

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-Imidazo[1,5-a][1,4]benzo-diazepine-3-carboxylic acid ethyl ester; Anexate; Flumazenil; Flumazepil; Flumenazil; Lanexat; Mazicon; FMZ; Ro 15-1788

CA index name: 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester


Research Chemical


Molar mass 303.29

CAS RN [78755-81-4]

Purity ≥ 95 %

  • Colorless crystals


CoA: appearance, ¹H and ¹⁹F NMR spectra


Nagren K. et al. Methylation of amide and thiol functions with [¹¹C]methyl triflate, as exemplified by [¹¹C]NMSP, [¹¹C]flumazenil and [¹¹C]methionine. J. Labelled Compd. Radiopharm. 1998, 41, 831–841.

Suzuki K. et al. Computer-Controlled Large Scale Production of High Specific Activity [¹¹C]Ro 15–1788 for PET Studies of Benzodiazepine Receptors. Int. J. Appl. Radiat. Isot. 1985, 36, 971–976.

Maziere M. et al. Synthesis of Ethyl-8-fluoro-5,6-dihydro-5-[¹¹C]methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (RO 15.1788–11C): A Specific Radioligand for the In Vivo Study of Central Benzodiazepine Receptors by Positron Emission Tomography. Int. J. Appl. Radiat. Isot. 1984, 35, 937–976.

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