[99mTc]Sestamibi [1] is myocardial perfusion imaging agent to visualize the blood flow through the heart. It is also used in the diagnosis of primary hyperparathyroidism to identify parathyroid adenomas, in radioactive surgery of the parathyroid gland and in the diagnosis of breast cancer [2]. ABX supplies the GMP precursor Copper tetraMIBI tetrafluoroborate for manufacture of [99mTc]Sestamibi cold kits with market approval in defined countries. The analytical methods and the precursor production process are fully validated.
[1] Lee T.-W. et al. Synthesis, reactivity and 99mTc labeling of 2-alkoxyisobutylisonitrile. Appl. Radiat. Isot.1996, 47, 207–210. [2] Rizk T.H., Nagalli S. Technetium 99m Sestamibi. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
ABX advanced biochemical compounds is a global frontrunner in radiopharmaceuticals, with a focus on positron emission tomography (PET) tracers. We develop and produce all compounds and components for any kind of radiotracer – from PET and SPECT precursors, PET reagent kits and cassettes, to complete radiopharmaceutical drug production in GMP environment.
Based in Radeberg, Germany, and founded in 1997, our team of about 400 employees is specialised in custom synthesis and manufacturing of precursors and peptides according to GMP for active pharmaceutical ingredients. Thanks to our expertise combined with bleeding edge equipment, we reach highest research, production, and quality standards.
ABX is the only service provider of radiopharmaceutical production with a complete and independent supply chain – from precursor or peptide to excipients and sterile disposables.
