Malignant melanoma is the most aggressive form of skin cancer, with one of the highest mortality rates. To improve the chances of successful treatment and survival, detection of primary and metastatic melanoma at an early stage is very important.N-(2-(dimethylamino)ethyl)-5-[18F]fluoropicolinamide ([18F]DMPY2) is a pyridine-based benzamide derivative having a high affinity and selectivity for melanin which is overexpressed in over 90% of melanomas and is closely associated with tumor heterogeneity and therapy response [1]. Compared to [18F]FDG which is currently used in clinics for malignant melanoma imaging, [18F]DMPY2 shows reduced susceptibility to inflammatory interference and is superior differentiating false-positive lesions in first clinical trials [2,3].
The precursor (ABX prod. no. 5770) to produce [18F]DMPY2 via a simple nucleophilic substitution reaction and its reference compound (ABX prod. no. 5771) are available for research and development.
[1] Pyo, A. Ultrasensitive detection of malignant melanoma using PET molecular imaging probes. PNAS 2020, 117 (23), 12991-12999. [2] Yang, Y. First-in-human PET imaging and evaluation of melanin-targeted [18F]DMPY2 in malignant melanoma patients. Theranostics 2025, 15 (13), 6100-6110. [3] Pyo, A. Comparative evaluation of [18F]DMPY2, [18F]P3BZA and [18F]FBZA for PET imaging of malignant melanoma in small animal models. JNM, 2021, 62 (supplement), 1471
ABX advanced biochemical compounds is a global frontrunner in radiopharmaceuticals, with a focus on positron emission tomography (PET) tracers. We develop and produce all compounds and components for any kind of radiotracer – from PET and SPECT precursors, PET reagent kits and cassettes, to complete radiopharmaceutical drug production in GMP environment.
Based in Radeberg, Germany, and founded in 1997, our team of about 400 employees is specialised in custom synthesis and manufacturing of precursors and peptides according to GMP for active pharmaceutical ingredients. Thanks to our expertise combined with bleeding edge equipment, we reach highest research, production, and quality standards.
ABX is the only service provider of radiopharmaceutical production with a complete and independent supply chain – from precursor or peptide to excipients and sterile disposables.
