Small molecules & peptides

Dimethoxybenzyl-FLT precursor

Precursor for [¹⁸F]FLT (3'-deoxy-3'-[¹⁸F]fluorothymidine)

3-N-(2,4-Dimethoxybenzyl)-1-[5-O-(4,4'-dimethoxytrityl)-3-O-nitrophenylsulfonyl-2-deoxy-β-D-lyxofuranosyl]thymidine; N-(2,4-Dimethoxybenzyl)-5'-O-dimethoxytrityl-3'-O-nosyl-thymidine; 2,4-(1H,3H)-Pyrimidinedione, 1-[5-O-[bis(4-methoxy-phenyl)phenylmethyl]-2-deoxy-3-O-[(4-nitrophenyl)sulfonyl]-β-D-threo-pentofuranosyl]-3-[(2,4-dimethoxyphenyl)methyl]-5-methyl-

CA index name: 2,4-(1H,3H)-Pyrimidinedione, 1-[5-O-[bis(4-methoxy-phenyl)phenylmethyl]-2-deoxy-3-O-[(4-nitrophenyl)sulfonyl]-β-D-threo-pentofuranosyl]-3-[(2,4-dimethoxyphenyl)methyl]-5-methyl-


Research Chemical


Molar mass 879.93

CAS RN [290371-75-4]

Purity ≥ 95 %

  • Yellowish to yellow solid


CoA: appearance, ¹H NMR spectrum


Shields A.F. et al. Imaging proliferation in vivo with [¹⁸F]FLT and positron emission tomography. Nature Medicine 1998, 4, 1334–1336.

Grierson J.R. et al. Developments in the radiosynthesis of [¹⁸F]FLT. J. Nucl. Med. 1998, 39, Proceedings of the 45th Annual Meeting, Toronto, Ontario, Canada, 22 P. No. 76.

Grierson J.R. et al. An improved radiosynthesis of [¹⁸F]FLT. J. Labelled Compd. Radiopharm. 1999, 42, Suppl. 1, S525.

Grierson J.R. et al. Radiosynthesis of 3'-deoxy-3'-[¹⁸F]fluoro-thymidine: [¹⁸F]FLT for imaging of cellular proliferation in vivo. Nucl. Med. Biol. 2000, 27, 143–156.

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