Small molecules & peptides

DMTr-Nosyl-lyxothymidine

Precursor for [¹⁸F]FLT (3'-deoxy-3'-[¹⁸F]fluorothymidine)

1-[5-O-(4,4'-Dimethoxytrityl)-3-O-nitrophenylsulfonyl-2-deoxy-β-D-lyxofuranosyl]thymine; 5'-O-Dimethoxytrityl-3'-O-nosyl-thymidine; 1-[5-O-(4,4'-Dimethoxytrityl)-3-O-nitrophenylsulfonyl-2-deoxy-β-D-threo-pentofuranosyl]-thymine; 2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-3-O-[(4-nitrophenyl)sulfonyl]-β-D-threo-pentofuranosyl]-5-methyl-; Non-Boc-FLT

CA index name: 2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-3-O-[(4-nitrophenyl)sulfonyl]-β-D-threo-pentofuranosyl]-5-methyl-

Quality

Research Chemical

Characteristics

Molar mass 729.75

CAS RN [444717-20-8]

Purity ≥ 90 %

  • Yellowish amorphous solid

Certificates

CoA: appearance, ¹H NMR spectrum

Literature

Oh S.J. et al. High radiochemical yield synthesis of 3'-deoxy-3'-[¹⁸F]Fluorothymidine using (5'-O-dimethoxytrityl-2'-deoxy-3'-O-nosyl-β-D-threo-pentofuranosyl)thymine and its 3-N-BOC-protected analogue as a labeling precursor. Nucl. Med. Biol. 2003, 30, 151–157.

Eisenhut M. et al. A new precursor for the radiosynthesis of [¹⁸F]FLT. Nucl. Med. Biol. 2002, 29, 263–273.

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