Qualität

Eigenschaften

Molare Masse 279.34

CAS RN [827031-83-4]

Reinheit ≥ 95 %

• white to off-white solid
• soluble in dimethyl sulfoxide, chloroform

Zertifikate

CoA: appearance, ¹H-and ¹³C-NMR spectra

Literatur

Kumar, J. S. D. et al. Radiosynthesis and in vivo evaluation of [¹¹C]MPC-6827, the first brain penetrant microtubule PET ligand J. Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.8b00028

Kumar J. S. D, Mann J. J. Radiolabeled microtubule imaging agents and uses thereof. 2017, US patent No. 62/578,903.

Sirisoma, N. et al. Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration J. Med. Chem. 2009 52 (8), 2341–2351.

Kasibhatla, S. et al. A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps. Cancer Research 2007, 67 (12), 5865—5871, DOI: 10.1158/0008–5472.CAN-07-0127.